YDJC

Across TCGA patient cohorts, YDJC mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YDJC-associated genes across cancer lineages are RPL7L1P4, RPS20P25, and RPS27P5. Each is linked with YDJC in more than 1 cancer types. Because this analysis shows association rather than direction, both YDJC-to-partner and partner-to-YDJC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL7L1P4 grouped by YDJC-low versus YDJC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YDJC→partner) and Y-score (partner→YDJC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL7L1P4 →	+0.066	+4.953	.001	.002	3	2
LUSC	RPS20P25 →	+0.150	+5.211	<.001	.007	3	1
LUSC	RPS27P5 →	+0.205	+4.984	<.001	.009	3	1
LUSC	RN7SL447P →	+0.251	+5.548	<.001	.004	3	1
LUSC	MIR3171 →	+0.655	+5.548	<.001	.004	3	1
LUSC	MIR4686 →	+0.728	+5.093	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

RPL7L1P4 by YDJC expression — SKCM

Explore this box plot interactively →