YDJC

Across TCGA pan-cancer cohorts, YDJC RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated YDJC data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher YDJC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated YDJC expression acts as an unfavorable survival marker, although some lineages such as SCLC and READ show a favorable association.

UVM, ACC, and LIHC are the cancer types where YDJC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.326	0.767	<.001	107	view →
ACC	DFS	Median	All	0.224	0.666	<.001	90	view →
LIHC	OS	Median	All	0.411	0.716	<.001	66	view →
KIRC	DFS	Quartile	All	0.514	0.702	<.001	52	view →
LGG	OS	Median	All	0.355	0.541	<.001	39	view →
LUAD	OS	Quartile	All	0.620	0.773	.001	36	view →
SCLC	OS	Quartile	All	0.601	0.267	.007	28	view →
KIRP	DFS	Median	All	0.866	0.949	.005	27	view →
SKCM	OS	Median	II,III,IV	0.224	0.380	.008	24	view →
KICH	OS	Quartile	III,IV	0.125	1.000	.017	17	view →
READ	OS	Quartile	All	1.000	0.717	.036	16	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

YDJC–UVM (OS)

Open the UVM breakdown →