YDJC

Across TCGA cell cohorts, YDJC mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible YDJC-associated genes across cancer lineages are MS4A4A, MSGN1, and TFDP3. Each is linked with YDJC in more than 1 cancer types. Because this analysis shows association rather than direction, both YDJC-to-partner and partner-to-YDJC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MS4A4A grouped by YDJC-low versus YDJC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YDJC→partner) and Y-score (partner→YDJC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MS4A4A →	+0.219	+3.678	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.100	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+4.196	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.329	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	NEXMIF →	+0.340	+4.196	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MS4A4A by YDJC expression — LARGE_INTESTINE

Explore this box plot interactively →