YBX1

Across TCGA patient cohorts, YBX1 mutation is significantly associated with the RNA expression of many other genes, with 1,988 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible YBX1-associated genes across cancer lineages are IFNA21, OR52Z1, and SENP3-EIF4A1. Each is linked with YBX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both YBX1-to-partner and partner-to-YBX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA21 grouped by YBX1-low versus YBX1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (YBX1→partner) and Y-score (partner→YBX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IFNA21 →	+0.117	+4.910	<.001	.002	3	1
COAD	OR52Z1 →	+0.079	+5.917	<.001	.001	3	1
UCEC	SENP3-EIF4A1 →	+0.132	+2.906	<.001	.001	3	1
UCEC	CISD3 →	+0.462	+2.823	.009	.001	3	1
UCEC	MYO19 →	+0.531	+3.831	<.001	<.001	3	1
UCEC	MIR6803 →	+0.130	+4.230	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,988 associations by consensus.

IFNA21 by YBX1 expression — COAD

Explore this box plot interactively →