YAE1

Across TCGA cell cohorts, YAE1 protein abundance is significantly associated with the go_rna of many other GO terms, with 950 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible YAE1-associated GO terms across cancer lineages are Neuroinflammatory response, Negative regulation of glucagon secretion, and Membrane fission. Each is linked with YAE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both YAE1-to-partner and partner-to-YAE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neuroinflammatory response grouped by YAE1-low versus YAE1-high in STOMACH.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (YAE1→partner) and Y-score (partner→YAE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Neuroinflammatory response →	-0.148	-0.836	.001	.002	3	3
STOMACH	Negative regulation of glucagon secretion →	+1.102	+0.847	.007	.001	3	3
STOMACH	Membrane fission →	-0.053	-0.982	.004	<.001	3	3
PANCREAS	Negative regulation of synaptic vesicle exocytosis →	-0.091	-1.057	.005	.004	3	3
LUNG_SCLC	Positive regulation of chromosome organization →	-0.062	-0.920	.005	.002	3	3
PANCREAS	Protein localization to chromosome, telomeric region →	-0.089	-1.381	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 950 associations by consensus.

Neuroinflammatory response by YAE1 expression — STOMACH

Explore this box plot interactively →