YAE1

Across TCGA pan-cancer cohorts, YAE1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of YAE1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where YAE1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types YAE1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where YAE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in YAE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.375	<.001	12	view →
LIHC	Male	II,III,IV	+0.949	<.001	9	view →
HNSC	All	III,IV	+0.429	<.001	9	view →
COAD	Male	All	+1.152	<.001	8	view →
KIRP	All	IV	+0.882	<.001	8	view →
LUAD	Male	All	+0.584	<.001	7	view →
CHOL	Female	All	+1.850	<.001	5	view →
THCA	Male	All	−0.368	<.001	5	view →
BRCA	All	II,III,IV	+0.222	<.001	4	view →
KICH	All	All	−0.549	<.001	3	view →
LUSC	Male	All	+0.449	<.001	2	view →
BLCA	All	All	+0.356	.035	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

YAE1–KIRC

Open the KIRC breakdown →