XYLB

Across TCGA patient cohorts, XYLB mutation is significantly associated with the RNA expression of many other genes, with 1,418 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XYLB-associated genes across cancer lineages are PMM2P1, BTBD6, and CISD3. Each is linked with XYLB in more than 2 cancer types. Because this analysis shows association rather than direction, both XYLB-to-partner and partner-to-XYLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PMM2P1 grouped by XYLB-low versus XYLB-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XYLB→partner) and Y-score (partner→XYLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PMM2P1 →	+0.076	+5.069	<.001	.008	3	3
UCEC	BTBD6 →	+0.323	+3.103	.003	<.001	3	3
UCEC	CISD3 →	+0.455	+1.874	.003	.002	3	2
HNSC	RPL9P15 →	+0.075	+5.578	.004	.004	3	2
BLCA	OR8A3P →	+0.086	+3.674	.001	.003	3	2
BLCA	MIR3684 →	+0.419	+3.255	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,418 associations by consensus.

PMM2P1 by XYLB expression — HNSC

Explore this box plot interactively →