XYLB

Across TCGA pan-cancer cohorts, XYLB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of XYLB’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where XYLB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types XYLB is over-expressed in tumor, although a few such as KICH and CHOL show the opposite, repressed pattern.

BLCA, LUAD, and LUSC are the cancer types where XYLB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XYLB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.938	<.001	11	view →
LUAD	Male	III,IV	+1.101	<.001	9	view →
LUSC	Male	III,IV	+1.579	<.001	8	view →
KICH	Female	All	−1.799	<.001	7	view →
STAD	Male	III,IV	+1.523	<.001	7	view →
UCEC	All	All	+0.659	<.001	6	view →
BRCA	All	III,IV	+0.637	<.001	6	view →
COAD	All	All	+0.365	<.001	4	view →
CHOL	All	All	−1.635	<.001	3	view →
PRAD	All	All	+0.669	<.001	2	view →
COAD	Female	IV	−0.555	.015	1	view →
LIHC	Male	All	+0.370	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

XYLB–BLCA

Open the BLCA breakdown →