XYLB

Across TCGA patient cohorts, XYLB mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XYLB-associated genes across cancer lineages are MSH2, 14-3-3_beta, and EGFR_pY1068. Each is linked with XYLB in more than 1 cancer types. Because this analysis shows association rather than direction, both XYLB-to-partner and partner-to-XYLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by XYLB-low versus XYLB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XYLB→partner) and Y-score (partner→XYLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.273	-2.295	.001	.033	3	2
UCEC	14-3-3_beta →	-0.082	-2.295	.023	.033	3	1
UCEC	EGFR_pY1068 →	-0.208	-1.925	.021	.005	3	1
UCEC	eIF4E →	+0.156	+1.584	.040	.019	3	1
UCEC	ERK2 →	+0.197	+2.321	.004	.001	3	1
UCEC	Fibronectin →	-0.279	-1.575	.018	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

MSH2 by XYLB expression — UCEC

Explore this box plot interactively →