XYLB

Across TCGA cell cohorts, XYLB mutation is significantly associated with the RNA expression of many other genes, with 112 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XYLB-associated genes across cancer lineages are FABP9, ACOT6, and DBX2. Each is linked with XYLB in more than 2 cancer types. Because this analysis shows association rather than direction, both XYLB-to-partner and partner-to-XYLB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FABP9 grouped by XYLB-low versus XYLB-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XYLB→partner) and Y-score (partner→XYLB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FABP9 →	+0.382	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	ACOT6 →	+0.047	+4.523	<.001	.004	3	1
LUNG_NSCLC_LUAD	DBX2 →	+0.014	+4.857	.002	.009	1	3
SKIN	OR1E3 →	+0.036	+6.022	<.001	.001	3	1
SKIN	OR1L3 →	+0.019	+5.415	<.001	.004	3	1
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 112 associations by consensus.

FABP9 by XYLB expression — BLOOD_Lymphoma

Explore this box plot interactively →