XXYLT1-AS2

Across TCGA pan-cancer cohorts, XXYLT1-AS2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated XXYLT1-AS2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher XXYLT1-AS2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated XXYLT1-AS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, KIRP, and LGG are the cancer types where XXYLT1-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.805	0.698	<.001	138	view →
KIRP	DFS	Quartile	All	0.462	0.819	.009	36	view →
LGG	OS	Tertile	All	0.741	0.861	.003	33	view →
CESC	DFS	Median	All	0.873	0.770	.010	30	view →
SKCM	DFS	Median	All	0.664	0.574	.012	23	view →
MESO	OS	Quartile	III,IV	0.459	0.263	.019	22	view →
ESCA	DFS	Median	III,IV	0.419	0.234	.009	21	view →
ACC	OS	Quartile	II,III,IV	0.375	0.702	.009	18	view →
THYM	DFS	Median	All	0.654	0.967	.005	16	view →
READ	DFS	Median	III,IV	0.879	0.591	.007	11	view →
BLCA	OS	Quartile	IV	0.705	0.294	.030	10	view →
SARC	OS	Quartile	All	0.946	0.771	.009	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

XXYLT1-AS2–HNSC (OS)

Open the HNSC breakdown →