XXYLT1-AS2

Across TCGA pan-cancer cohorts, XXYLT1-AS2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of XXYLT1-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where XXYLT1-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types XXYLT1-AS2 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, LUSC, and KIRC are the cancer types where XXYLT1-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XXYLT1-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.356	<.001	8	view →
LUSC	All	All	−0.316	<.001	7	view →
KIRC	Male	All	+0.210	<.001	7	view →
BLCA	All	All	−0.692	.001	6	view →
KICH	All	All	−0.384	.006	3	view →
COAD	All	All	−0.331	.004	3	view →
UCEC	All	All	−0.309	.004	2	view →
BRCA	All	III,IV	−0.226	.008	2	view →
LIHC	Male	All	−0.087	.017	2	view →
READ	Female	All	−0.562	.047	1	view →
LUAD	All	III,IV	−0.348	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

XXYLT1-AS2–THCA

Open the THCA breakdown →