XXYLT1-AS1

Across TCGA pan-cancer cohorts, XXYLT1-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of XXYLT1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where XXYLT1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types XXYLT1-AS1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, HNSC, and KICH are the cancer types where XXYLT1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XXYLT1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.449	<.001	9	view →
HNSC	Male	All	+0.311	.001	8	view →
KICH	Male	All	−0.944	<.001	7	view →
LUSC	Female	II,III,IV	+1.158	<.001	6	view →
THCA	All	All	−0.098	.015	5	view →
LUAD	Female	All	+0.299	<.001	3	view →
BLCA	All	All	+0.281	.009	3	view →
ESCA	All	II,III,IV	+0.360	.018	2	view →
BRCA	All	III,IV	−0.195	.005	2	view →
COAD	Female	III,IV	−0.334	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

XXYLT1-AS1–KIRC

Open the KIRC breakdown →