XRN2

Across TCGA patient cohorts, XRN2 mutation is significantly associated with the RNA expression of many other genes, with 3,720 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRN2-associated genes across cancer lineages are FCER1A, MRPS18C, and CD207. Each is linked with XRN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both XRN2-to-partner and partner-to-XRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER1A grouped by XRN2-low versus XRN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRN2→partner) and Y-score (partner→XRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCER1A →	-0.843	-2.362	<.001	<.001	3	3
UCEC	MRPS18C →	+0.271	+1.390	.002	.002	3	3
UCEC	CD207 →	-0.800	-4.159	<.001	<.001	3	3
LIHC	KRT18P9 →	+0.047	+3.397	<.001	.003	3	2
BLCA	TMEM225 →	+0.063	+4.497	<.001	.005	3	2
SKCM	RPS14P7 →	+0.228	+4.797	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,720 associations by consensus.

FCER1A by XRN2 expression — UCEC

Explore this box plot interactively →