XRN2

Across TCGA pan-cancer cohorts, XRN2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated XRN2 data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher XRN2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated XRN2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and READ show a favorable association.

MESO, KIRC, and LGG are the cancer types where XRN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	III,IV	0.214	0.478	<.001	96	view →
KIRC	DFS	Median	All	0.709	0.543	.001	65	view →
LGG	OS	Median	All	0.384	0.528	<.001	46	view →
LIHC	OS	Median	All	0.601	0.767	<.001	41	view →
LUAD	DFS	Median	IV	0.406	0.817	.007	36	view →
PAAD	OS	Tertile	All	0.492	0.752	.006	30	view →
CESC	DFS	Quartile	All	0.750	0.848	.018	18	view →
READ	OS	Tertile	All	0.867	0.516	.015	17	view →
BLCA	DFS	Quartile	All	0.199	0.585	.002	15	view →
SARC	OS	Median	All	0.432	0.761	<.001	12	view →
SKCM	DFS	Quartile	All	0.721	0.538	.002	9	view →
UVM	DFS	Quartile	All	0.338	0.749	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

XRN2–MESO (DFS)

Open the MESO breakdown →