XRN2

Across TCGA patient cohorts, XRN2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRN2-associated genes across cancer lineages are ERK2, Cyclin-E2, and eIF4E. Each is linked with XRN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRN2-to-partner and partner-to-XRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by XRN2-low versus XRN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRN2→partner) and Y-score (partner→XRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.132	+1.184	.022	.022	3	2
UCEC	Cyclin-E2 →	+0.135	+1.402	.007	.011	3	2
COAD	eIF4E →	+0.219	+2.820	.018	.035	2	2
UCEC	14-3-3_beta →	-0.075	-1.973	.012	.008	3	1
UCEC	EGFR_pY1068 →	-0.194	-1.584	.009	.002	3	1
UCEC	A-Raf_pS299 →	-0.090	-1.678	.011	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ERK2 by XRN2 expression — UCEC

Explore this box plot interactively →