XRN2

Across TCGA cell cohorts, XRN2 mutation is significantly associated with the RNA expression of many other genes, with 1,329 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XRN2-associated genes across cancer lineages are OR9G1, SLC22A24, and WFDC6. Each is linked with XRN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRN2-to-partner and partner-to-XRN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9G1 grouped by XRN2-low versus XRN2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRN2→partner) and Y-score (partner→XRN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	OR9G1 →	+0.113	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	SLC22A24 →	+0.006	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	WFDC6 →	+0.060	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	OR1D5 →	+0.090	+4.643	<.001	.008	3	2
LARGE_INTESTINE	LRRC3C →	+0.174	+2.506	.004	<.001	3	2
LARGE_INTESTINE	C19orf85 →	+0.247	+2.169	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,329 associations by consensus.

OR9G1 by XRN2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →