XRN1

Across TCGA patient cohorts, XRN1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,096 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible XRN1-associated proteins across cancer lineages are PARP9, STAT1, and PSMB7. Each is linked with XRN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both XRN1-to-partner and partner-to-XRN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XRN1 versus PARP9 in HNSC, with a Pearson correlation of 0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XRN1→partner) and Y-score (partner→XRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PARP9 →	+0.545	+0.676	<.001	<.001	3	6
COAD	STAT1 →	+0.664	+0.539	<.001	.001	3	6
CCRCC	PSMB7 →	-0.422	-0.399	<.001	<.001	3	5
HNSC	GBP1 →	+0.905	+0.518	<.001	.001	2	6
HNSC	GBP4 →	+0.841	+0.622	<.001	<.001	3	5
HNSC	STAT2 →	+0.529	+0.563	<.001	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,096 associations by consensus.

XRN1 vs PARP9 — HNSC

Explore this scatter interactively →