XRN1

Across TCGA patient cohorts, XRN1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,791 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible XRN1-associated genes across cancer lineages are GBP1, STAT1, and TAP2. Each is linked with XRN1 in more than 6 cancer types. Because this analysis shows association rather than direction, both XRN1-to-partner and partner-to-XRN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XRN1 versus GBP1 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRN1→partner) and Y-score (partner→XRN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBP1 →	+1.267	+0.200	<.001	.002	3	7
COAD	STAT1 →	+0.959	+0.226	<.001	<.001	3	7
UCEC	TAP2 →	+0.825	+0.207	<.001	<.001	3	7
COAD	PARP9 →	+0.907	+0.203	<.001	<.001	3	6
BRCA	CXCL9 →	+2.033	+0.220	<.001	<.001	3	6
COAD	WARS1 →	+1.237	+0.194	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,791 associations by consensus.

XRN1 vs GBP1 — BRCA

Explore this scatter interactively →