XRCC5

Across TCGA cell cohorts, XRCC5 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XRCC5-associated genes across cancer lineages are TECRL, OR10G2, and CRYBB3. Each is linked with XRCC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC5-to-partner and partner-to-XRCC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TECRL grouped by XRCC5-low versus XRCC5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC5→partner) and Y-score (partner→XRCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TECRL →	+0.048	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR10G2 →	+0.026	+4.212	<.001	.007	3	1
BLOOD_Leukemia	CRYBB3 →	+0.104	+4.152	<.001	.009	3	1
BLOOD_Leukemia	LMX1A →	+0.172	+4.409	<.001	.005	3	1
BLOOD_Leukemia	TMEM196 →	+0.053	+4.874	<.001	.002	3	1
BLOOD_Leukemia	OR8D4 →	+0.004	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

TECRL by XRCC5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →