XRCC4

Across TCGA patient cohorts, XRCC4 mutation is significantly associated with the RNA expression of many other genes, with 1,772 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRCC4-associated genes across cancer lineages are STAU2P1, RNU6-1213P, and WDR82P2. Each is linked with XRCC4 in more than 2 cancer types. Because this analysis shows association rather than direction, both XRCC4-to-partner and partner-to-XRCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAU2P1 grouped by XRCC4-low versus XRCC4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC4→partner) and Y-score (partner→XRCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	STAU2P1 →	+0.298	+3.387	<.001	.007	3	3
UCEC	RNU6-1213P →	+0.165	+3.555	<.001	.002	3	3
COAD	WDR82P2 →	+0.439	+3.668	<.001	.007	3	2
COAD	RPS15AP32 →	+0.236	+4.392	<.001	.006	3	2
UCEC	MIR3661 →	+0.733	+2.114	<.001	.002	3	2
BLCA	CCDC75P1 →	+0.091	+4.973	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,772 associations by consensus.

STAU2P1 by XRCC4 expression — COAD

Explore this box plot interactively →