XRCC4

Across TCGA patient cohorts, XRCC4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRCC4-associated genes across cancer lineages are eEF2, JNK_pT183_Y185, and mTOR_pS2448. Each is linked with XRCC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both XRCC4-to-partner and partner-to-XRCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by XRCC4-low versus XRCC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC4→partner) and Y-score (partner→XRCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.457	+2.000	.004	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.165	-2.459	.029	.019	3	1
UCEC	mTOR_pS2448 →	-0.162	-2.439	.015	.019	3	1
UCEC	P-Cadherin →	-0.147	-2.999	.023	.035	3	1
UCEC	PCNA →	+0.193	+2.321	.048	.034	3	1
UCEC	PDCD4 →	-0.506	-2.312	.017	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by XRCC4 expression — UCEC

Explore this box plot interactively →