XRCC4

Across TCGA cell cohorts, XRCC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,644 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible XRCC4-associated GO terms across cancer lineages are Regulation of phospholipid translocation, Positive regulation of phospholipid translocation, and Positive regulation of ligase activity. Each is linked with XRCC4 in more than 19 cancer types. Because this analysis shows association rather than direction, both XRCC4-to-partner and partner-to-XRCC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of phospholipid translocation grouped by XRCC4-low versus XRCC4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC4→partner) and Y-score (partner→XRCC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of phospholipid translocation →	+0.267	+1.022	<.001	<.001	3	20
BREAST	Positive regulation of phospholipid translocation →	+0.267	+1.022	<.001	<.001	3	20
SOFT_TISSUE	Positive regulation of ligase activity →	+0.147	+0.999	<.001	<.001	3	17
SOFT_TISSUE	Immunoglobulin V(D)J recombination →	+0.146	+0.955	<.001	<.001	3	14
BREAST	Chromosome localization →	+0.111	+0.589	<.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of chromosome separation →	+0.157	+0.885	.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,644 associations by consensus.

Regulation of phospholipid translocation by XRCC4 expression — BREAST

Explore this box plot interactively →