XRCC1

Across TCGA patient cohorts, XRCC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,514 significant associations in total. GBM shows the largest number of these associations.

The most reproducible XRCC1-associated proteins across cancer lineages are TRIM28, XRCC1_S447, and LIG1. Each is linked with XRCC1 in more than 6 cancer types. Because this analysis shows association rather than direction, both XRCC1-to-partner and partner-to-XRCC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XRCC1 versus TRIM28 in GBM, with a Pearson correlation of 0.63.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC1→partner) and Y-score (partner→XRCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TRIM28 →	+0.403	+0.390	<.001	<.001	3	7
GBM	XRCC1_S447 →	+0.527	+0.290	<.001	<.001	3	7
GBM	LIG1 →	+0.532	+0.438	<.001	<.001	3	6
OV	PAFAH1B3 →	+0.574	+0.635	<.001	.002	3	6
BRCA	ZNF219_S114 →	+0.764	+0.457	<.001	.001	3	5
HNSC	CBX1 →	+0.477	+0.549	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,514 associations by consensus.

XRCC1 vs TRIM28 — GBM

Explore this scatter interactively →