XRCC1

Across TCGA pan-cancer cohorts, XRCC1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated XRCC1 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher XRCC1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated XRCC1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LUSC show a favorable association.

MESO, ACC, and LGG are the cancer types where XRCC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Quartile	All	0.310	0.539	.004	66	view →
ACC	DFS	Median	All	0.428	0.731	<.001	62	view →
LGG	DFS	Median	All	0.660	0.817	<.001	53	view →
SCLC	DFS	Tertile	III,IV	0.840	0.399	.004	47	view →
LIHC	DFS	Tertile	All	0.426	0.608	<.001	46	view →
LUSC	OS	Tertile	All	0.703	0.561	.002	31	view →
BRCA	OS	Quartile	III,IV	0.963	0.841	.008	24	view →
HNSC	DFS	Median	IV	0.707	0.575	.002	24	view →
LUAD	DFS	Median	All	0.614	0.710	.013	22	view →
GBM	DFS	Tertile	All	0.426	0.140	<.001	21	view →
CHOL	OS	Tertile	All	1.000	0.244	.011	18	view →
KIRC	DFS	Quartile	All	0.672	0.434	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

XRCC1–MESO (DFS)

Open the MESO breakdown →