XRCC1

Across TCGA patient cohorts, XRCC1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XRCC1-associated genes across cancer lineages are ATM, PDCD4, and Rad50. Each is linked with XRCC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both XRCC1-to-partner and partner-to-XRCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by XRCC1-low versus XRCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC1→partner) and Y-score (partner→XRCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.537	-3.446	.002	.005	3	3
UCEC	PDCD4 →	-0.510	-2.502	.005	.002	3	2
UCEC	Rad50 →	-0.241	-2.000	.011	.010	3	2
UCEC	GAPDH →	+0.504	+2.321	.016	.033	3	1
UCEC	Ku80 →	+0.226	+2.013	.014	.005	3	1
UCEC	MEK1 →	+0.634	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by XRCC1 expression — UCEC

Explore this box plot interactively →