XRCC1

Across TCGA cell cohorts, XRCC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,437 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XRCC1-associated GO terms across cancer lineages are Regulation of base-excision repair, Telomeric DNA-containing double minutes formation, and Regulation of protection from non-homologous end joining at telomere. Each is linked with XRCC1 in more than 19 cancer types. Because this analysis shows association rather than direction, both XRCC1-to-partner and partner-to-XRCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of base-excision repair grouped by XRCC1-low versus XRCC1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XRCC1→partner) and Y-score (partner→XRCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Regulation of base-excision repair →	+0.160	+0.940	<.001	<.001	3	20
LIVER	Telomeric DNA-containing double minutes formation →	+0.181	+0.726	.001	<.001	3	18
LIVER	Regulation of protection from non-homologous end joining at telomere →	+0.181	+0.726	.001	<.001	3	18
LIVER	Negative regulation of protection from non-homologous end joining at telomere →	+0.181	+0.726	.001	<.001	3	18
BLOOD_Lymphoma	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.132	+0.858	<.001	<.001	3	17
OESOPHAGUS	Negative regulation of calcium ion export across plasma membrane →	+0.087	+0.932	.007	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,437 associations by consensus.

Regulation of base-excision repair by XRCC1 expression — STOMACH

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