XPR1

Across TCGA patient cohorts, XPR1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,854 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible XPR1-associated genes across cancer lineages are GALNT2, TXLNB, and PLS3. Each is linked with XPR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both XPR1-to-partner and partner-to-XPR1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XPR1 versus GALNT2 in LUAD, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPR1→partner) and Y-score (partner→XPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GALNT2 →	+0.590	+0.957	<.001	<.001	3	4
OV	TXLNB →	-0.710	-0.852	.002	.001	3	4
LUAD	PLS3 →	+0.999	+0.760	<.001	<.001	3	3
LSCC	CLIP4 →	+0.977	+0.596	<.001	<.001	3	3
HNSC	SPP1 →	+2.003	+0.445	<.001	.002	3	3
HNSC	PTGFRN →	+0.648	+0.343	.001	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,854 associations by consensus.

XPR1 vs GALNT2 — LUAD

Explore this scatter interactively →