XPR1

Across TCGA pan-cancer cohorts, XPR1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of XPR1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where XPR1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types XPR1 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

HNSC, LUAD, and THCA are the cancer types where XPR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XPR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.919	<.001	12	view →
LUAD	Male	III,IV	+2.099	<.001	11	view →
THCA	Female	III,IV	+1.415	<.001	11	view →
BLCA	Female	III,IV	+1.657	<.001	10	view →
STAD	All	II,III,IV	+0.939	<.001	10	view →
LIHC	Male	All	+1.275	<.001	9	view →
KICH	Female	All	−1.627	<.001	8	view →
LUSC	Female	All	+1.330	<.001	8	view →
UCEC	All	II,III,IV	+1.476	<.001	6	view →
BRCA	All	II,III,IV	+0.682	<.001	6	view →
CHOL	Female	All	+2.743	<.001	5	view →
KIRP	All	II,III,IV	+0.511	.017	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

XPR1–HNSC

Open the HNSC breakdown →