XPR1

Across TCGA patient cohorts, XPR1 mutation is significantly associated with the RNA expression of many other genes, with 3,897 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPR1-associated genes across cancer lineages are TRMU, GTSE1, and E2F2. Each is linked with XPR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both XPR1-to-partner and partner-to-XPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRMU grouped by XPR1-low versus XPR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPR1→partner) and Y-score (partner→XPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRMU →	+0.556	+1.893	<.001	<.001	3	4
UCEC	GTSE1 →	+0.794	+2.922	<.001	<.001	3	4
UCEC	E2F2 →	+0.604	+2.868	<.001	<.001	3	4
UCEC	CRELD2 →	+0.397	+1.789	.006	.008	3	4
UCEC	C4orf46 →	+0.551	+1.665	<.001	.002	3	4
UCEC	UHRF1 →	+0.897	+2.496	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,897 associations by consensus.

TRMU by XPR1 expression — UCEC

Explore this box plot interactively →