XPR1

Across TCGA cell cohorts, XPR1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XPR1-associated genes across cancer lineages are AVP, HOXB1, and MAGEB4. Each is linked with XPR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XPR1-to-partner and partner-to-XPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by XPR1-low versus XPR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPR1→partner) and Y-score (partner→XPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.048	+3.217	<.001	.006	3	1
LARGE_INTESTINE	HOXB1 →	+0.018	+4.113	.004	.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	OBP2A →	+0.115	+2.878	<.001	.009	3	1
LARGE_INTESTINE	LMNTD1 →	+0.183	+2.969	<.001	.007	3	1
LARGE_INTESTINE	GOT1L1 →	+0.020	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

AVP by XPR1 expression — LARGE_INTESTINE

Explore this box plot interactively →