XPO5

Across TCGA cell cohorts, XPO5 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XPO5-associated genes across cancer lineages are PYDC1, HES3, and CA5A. Each is linked with XPO5 in more than 1 cancer types. Because this analysis shows association rather than direction, both XPO5-to-partner and partner-to-XPO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYDC1 grouped by XPO5-low versus XPO5-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO5→partner) and Y-score (partner→XPO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PYDC1 →	+0.139	+5.087	<.001	.004	3	1
URINARY_TRACT	HES3 →	+0.040	+5.087	<.001	.004	3	1
URINARY_TRACT	CA5A →	+0.020	+5.087	<.001	.004	3	1
URINARY_TRACT	OR4N4 →	+0.030	+5.087	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PYDC1 by XPO5 expression — URINARY_TRACT

Explore this box plot interactively →