XPO4

Across TCGA pan-cancer cohorts, XPO4 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated XPO4 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher XPO4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated XPO4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, UCEC, and LUAD are the cancer types where XPO4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.169	0.931	<.001	33	view →
UCEC	DFS	Median	All	0.946	0.606	.003	32	view →
LUAD	OS	Median	II,III,IV	0.090	0.709	<.001	12	view →
BRCA	DFS	Median	II,III,IV	0.615	0.889	.001	10	view →
READ	OS	Median	II,III,IV	0.187	0.653	.030	6	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
PRAD	DFS	Median	All	0.617	0.886	.037	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

XPO4–THYM (OS)

Open the THYM breakdown →