XPO4

Across TCGA pan-cancer cohorts, XPO4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of XPO4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where XPO4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types XPO4 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

COAD, THCA, and STAD are the cancer types where XPO4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XPO4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	+1.025	<.001	11	view →
THCA	All	II,III,IV	−0.652	<.001	9	view →
STAD	Male	II,III,IV	+1.070	<.001	7	view →
LIHC	Female	II,III,IV	+0.650	<.001	7	view →
LUAD	Female	II,III,IV	−0.919	<.001	6	view →
LUSC	All	All	−0.382	<.001	6	view →
BLCA	All	All	+0.383	.025	5	view →
READ	All	III,IV	+1.279	<.001	4	view →
CHOL	All	All	+1.274	<.001	4	view →
ESCA	All	All	+0.995	.011	2	view →
HNSC	All	II,III,IV	+0.296	.036	2	view →
PAAD	Male	All	+0.285	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

XPO4–COAD

Open the COAD breakdown →