XPO4

Across TCGA patient cohorts, XPO4 mutation is significantly associated with the RNA expression of many other genes, with 6,303 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPO4-associated genes across cancer lineages are GNPNAT1, EXPH5, and TTC19. Each is linked with XPO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both XPO4-to-partner and partner-to-XPO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by XPO4-low versus XPO4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO4→partner) and Y-score (partner→XPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNPNAT1 →	+0.733	+1.776	<.001	<.001	3	3
UCEC	EXPH5 →	+0.479	+2.083	<.001	<.001	3	3
UCEC	TTC19 →	+0.570	+2.963	<.001	<.001	3	3
UCEC	PLS1 →	+0.574	+2.094	.001	<.001	3	3
UCEC	EXOSC9 →	+0.400	+2.191	<.001	<.001	3	3
UCEC	GRSF1 →	+0.384	+2.459	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,303 associations by consensus.

GNPNAT1 by XPO4 expression — UCEC

Explore this box plot interactively →