XPO4

Across TCGA patient cohorts, XPO4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPO4-associated genes across cancer lineages are JNK_pT183_Y185, ASNS, and eEF2. Each is linked with XPO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both XPO4-to-partner and partner-to-XPO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by XPO4-low versus XPO4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO4→partner) and Y-score (partner→XPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	JNK_pT183_Y185 →	-0.245	-3.000	.045	.035	3	2
COAD	ASNS →	+0.685	+2.178	<.001	.035	3	2
UCEC	eEF2 →	+0.211	+2.115	.043	.016	3	2
UCEC	Gab2 →	+0.309	+1.736	.002	.006	3	2
UCEC	PCNA →	+0.172	+1.678	.006	.019	3	2
UCEC	Annexin-1 →	+0.576	+2.341	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

JNK_pT183_Y185 by XPO4 expression — COAD

Explore this box plot interactively →