XPO4

Across TCGA cell cohorts, XPO4 mutation is significantly associated with the RNA expression of many other genes, with 247 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XPO4-associated genes across cancer lineages are SLC6A18, PLRG1, and TRIM64B. Each is linked with XPO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both XPO4-to-partner and partner-to-XPO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC6A18 grouped by XPO4-low versus XPO4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO4→partner) and Y-score (partner→XPO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC6A18 →	+0.188	+3.363	<.001	.004	3	2
BLOOD_Leukemia	PLRG1 →	+0.376	+3.489	.007	.001	3	2
UPPER_AERODIGESTIVE_TRACT	TRIM64B →	+0.014	+4.870	<.001	.001	3	1
LARGE_INTESTINE	KCNK17 →	+0.050	+2.584	.001	.004	3	1
LARGE_INTESTINE	RWDD2A →	+0.596	+3.299	<.001	.004	3	1
LARGE_INTESTINE	ATP5F1A →	+0.748	+3.212	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 247 associations by consensus.

SLC6A18 by XPO4 expression — LARGE_INTESTINE

Explore this box plot interactively →