XPO1

Across TCGA cell cohorts, XPO1 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XPO1-associated genes across cancer lineages are MRGPRG, OR14K1, and LIPN. Each is linked with XPO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XPO1-to-partner and partner-to-XPO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRG grouped by XPO1-low versus XPO1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO1→partner) and Y-score (partner→XPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MRGPRG →	+0.142	+4.736	<.001	.009	3	2
LUNG_SCLC	OR14K1 →	+0.101	+4.269	<.001	.005	3	1
LUNG_NSCLC_LUAD	LIPN →	+0.039	+4.947	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR10G2 →	+0.036	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	TEX49 →	+0.114	+4.544	<.001	.003	3	1
BLOOD_Leukemia	ANKRD30BL →	+0.665	+3.289	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MRGPRG by XPO1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →