Across TCGA pan-cancer cohorts, XPNPEP3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated XPNPEP3 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher XPNPEP3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated XPNPEP3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

CCRCC, LSCC, and LUAD are the cancer types where XPNPEP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.379	0.805	.011	15	view →
LSCC	DFS	Tertile	All	0.720	0.909	.021	6	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	4	view →
PDAC	DFS	Tertile	IV	0.741	0.203	.024	3	view →
GBM	OS	Quartile	All	0.607	0.412	.049	2	view →
HNSC	DFS	Median	III,IV	0.937	1.000	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: XPNPEP3 tumor-vs-normal RNA expression · all XPNPEP3 data types