Across TCGA pan-cancer cohorts, XPNPEP3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of XPNPEP3’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where XPNPEP3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types XPNPEP3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
COAD, THCA, and HNSC are the cancer types where XPNPEP3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XPNPEP3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.