XPC

Across TCGA patient cohorts, XPC mutation is significantly associated with the RNA expression of many other genes, with 1,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPC-associated genes across cancer lineages are MIR504, RNU6-451P, and RNU6-1127P. Each is linked with XPC in more than 1 cancer types. Because this analysis shows association rather than direction, both XPC-to-partner and partner-to-XPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR504 grouped by XPC-low versus XPC-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPC→partner) and Y-score (partner→XPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR504 →	+0.288	+5.584	<.001	.001	3	2
UCEC	RNU6-451P →	+0.419	+2.386	<.001	.002	3	2
COAD	RNU6-1127P →	+0.308	+4.721	.002	.004	3	2
COAD	RPL32P19 →	+0.222	+4.017	<.001	.003	3	2
COAD	MTND4LP2 →	+0.189	+4.721	<.001	.004	3	2
UCEC	SIRT6 →	+0.363	+2.180	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,189 associations by consensus.

MIR504 by XPC expression — CESC

Explore this box plot interactively →