XPA

Across TCGA patient cohorts, XPA protein abundance is significantly associated with the RNA expression of many other genes, with 12,409 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible XPA-associated genes across cancer lineages are ZNF510, ZNF189, and SECISBP2. Each is linked with XPA in more than 6 cancer types. Because this analysis shows association rather than direction, both XPA-to-partner and partner-to-XPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XPA versus ZNF510 in OV, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPA→partner) and Y-score (partner→XPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF510 →	+0.485	+0.332	.005	<.001	3	7
HNSC	ZNF189 →	+0.961	+0.387	<.001	<.001	3	6
BRCA	SECISBP2 →	+0.704	+0.403	<.001	<.001	3	6
HNSC	MRPL50 →	+0.777	+0.360	.004	<.001	3	6
OV	TRMO →	+0.616	+0.467	<.001	<.001	3	6
LSCC	CNTRL →	+0.519	+0.308	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,409 associations by consensus.

XPA vs ZNF510 — OV

Explore this scatter interactively →