XPA

Across TCGA pan-cancer cohorts, XPA RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of XPA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where XPA RNA is repressed in tumor relative to normal tissue. In most cancer types XPA is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and BLCA are the cancer types where XPA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in XPA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.672	<.001	12	view →
THCA	Male	IV	−1.486	<.001	10	view →
BLCA	Male	III,IV	−1.028	<.001	8	view →
LUAD	Female	III,IV	−0.721	<.001	8	view →
KICH	Male	All	−1.072	<.001	7	view →
KIRP	Male	All	−0.904	<.001	7	view →
UCEC	All	All	−0.913	<.001	6	view →
BRCA	Female	II,III,IV	−0.462	<.001	6	view →
LIHC	All	All	+0.351	<.001	6	view →
CHOL	All	All	+0.624	.022	1	view →
ESCA	Female	All	−0.436	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

XPA–KIRC

Open the KIRC breakdown →