XPA

Across TCGA patient cohorts, XPA mutation is significantly associated with the RNA expression of many other genes, with 447 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPA-associated genes across cancer lineages are RNU6-694P, RAP2CP1, and CCL5. Each is linked with XPA in more than 1 cancer types. Because this analysis shows association rather than direction, both XPA-to-partner and partner-to-XPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-694P grouped by XPA-low versus XPA-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPA→partner) and Y-score (partner→XPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-694P →	+0.590	+6.478	<.001	<.001	3	2
UCEC	RAP2CP1 →	+0.737	+3.595	<.001	.001	3	1
UCEC	CCL5 →	+1.104	+3.475	.004	.002	3	1
UCEC	LINC01607 →	-0.756	-3.568	<.001	.002	3	1
UCEC	CCL4 →	+0.903	+2.243	.002	.006	3	1
UCEC	MIR6821 →	+0.339	+2.092	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 447 associations by consensus.

RNU6-694P by XPA expression — COAD

Explore this box plot interactively →