XPA

Across TCGA cell cohorts, XPA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,153 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XPA-associated GO terms across cancer lineages are Nucleotide-excision repair, Regulation of DNA damage checkpoint, and Cap-dependent translational initiation. Each is linked with XPA in more than 13 cancer types. Because this analysis shows association rather than direction, both XPA-to-partner and partner-to-XPA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleotide-excision repair grouped by XPA-low versus XPA-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XPA→partner) and Y-score (partner→XPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Nucleotide-excision repair →	+0.059	+0.648	<.001	<.001	3	14
BLOOD_Leukemia	Regulation of DNA damage checkpoint →	+0.065	+0.610	<.001	<.001	3	12
CNS	Cap-dependent translational initiation →	+0.094	+0.448	<.001	<.001	3	11
BLOOD_Leukemia	Positive regulation of RNA splicing →	+0.054	+0.467	.007	.006	3	11
BLOOD_Leukemia	Positive regulation of chromosome condensation →	+0.128	+0.627	<.001	<.001	3	10
BLOOD_Leukemia	Immunoglobulin heavy chain V-D-J recombination →	+0.130	+0.611	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,153 associations by consensus.

Nucleotide-excision repair by XPA expression — OVARY

Explore this box plot interactively →