XPA

Across TCGA cell cohorts, XPA protein abundance is significantly associated with the RNA expression of many other genes, with 2,022 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XPA-associated genes across cancer lineages are PRCP, SMPD1, and PPP2R5B. Each is linked with XPA in more than 5 cancer types. Because this analysis shows association rather than direction, both XPA-to-partner and partner-to-XPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XPA versus PRCP in LARGE_INTESTINE, with a Pearson correlation of 0.57.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPA→partner) and Y-score (partner→XPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRCP →	+1.114	+1.117	<.001	.003	3	6
SKIN	SMPD1 →	+0.817	+0.871	.007	<.001	3	6
SKIN	PPP2R5B →	+1.423	+1.068	<.001	<.001	3	6
URINARY_TRACT	PDRG1 →	+0.722	+0.831	.003	.001	3	5
LIVER	GMPPA →	+1.202	+2.045	.002	.001	3	5
LIVER	TOP1MT →	-0.964	-1.214	.006	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,022 associations by consensus.

XPA vs PRCP — LARGE_INTESTINE

Explore this scatter interactively →