XKR7

Across TCGA cell cohorts, XKR7 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XKR7-associated genes across cancer lineages are OR7D4, OR10G2, and CCNB1IP1. Each is linked with XKR7 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR7-to-partner and partner-to-XKR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7D4 grouped by XKR7-low versus XKR7-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR7→partner) and Y-score (partner→XKR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR7D4 →	+0.056	+5.196	<.001	.005	3	1
OVARY	OR10G2 →	+0.026	+5.196	<.001	.005	3	1
LARGE_INTESTINE	CCNB1IP1 →	+0.832	+3.212	<.001	.006	3	1
LARGE_INTESTINE	FGF8 →	+0.330	+3.212	.001	.006	3	1
LARGE_INTESTINE	FAM149A →	+1.832	+3.082	<.001	.007	3	1
LARGE_INTESTINE	PLA2G4A →	+2.077	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

OR7D4 by XKR7 expression — OVARY

Explore this box plot interactively →