XKR3

Across TCGA patient cohorts, XKR3 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XKR3-associated genes across cancer lineages are IGFBP2, Annexin-1, and CD49b. Each is linked with XKR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR3-to-partner and partner-to-XKR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by XKR3-low versus XKR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR3→partner) and Y-score (partner→XKR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.547	-1.502	.022	.030	3	2
UCEC	Annexin-1 →	+0.531	+2.019	.006	.017	3	2
UCEC	CD49b →	-0.206	-2.302	.049	.034	3	2
LUSC	ACC_pS79 →	+0.472	+2.179	.004	.035	3	1
LUSC	HER2 →	+0.411	+2.179	.018	.035	3	1
UCEC	EGFR_pY1068 →	-0.233	-1.847	.011	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

IGFBP2 by XKR3 expression — UCEC

Explore this box plot interactively →