XKR3

Across TCGA pan-cancer cohorts, XKR3 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated XKR3 data layer compared with 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher XKR3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated XKR3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and THYM show a favorable association.

LUSC, READ, and MESO are the cancer types where XKR3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	III,IV	0.523	0.792	<.001	77	view →
READ	OS	Tertile	All	0.199	0.720	<.001	75	view →
MESO	DFS	Median	III,IV	0.256	0.487	.001	51	view →
THCA	DFS	Quartile	IV	0.587	1.000	.003	26	view →
SCLC	DFS	Tertile	All	0.256	0.712	.018	22	view →
HNSC	DFS	Quartile	IV	0.461	0.293	.009	18	view →
THYM	OS	Median	All	0.966	0.777	.003	13	view →
SARC	OS	Median	All	0.628	0.297	.001	12	view →
KIRP	DFS	Tertile	III,IV	0.394	0.699	.019	11	view →
LIHC	OS	Median	All	0.389	0.635	.017	9	view →
ACC	OS	Tertile	IV	0.869	0.393	.006	9	view →
DLBC	OS	Median	All	0.952	0.537	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

XKR3–LUSC (OS)

Open the LUSC breakdown →