XKR3

Across TCGA cell cohorts, XKR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 937 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible XKR3-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Nephron epithelium development, and Melanosome organization. Each is linked with XKR3 in more than 5 cancer types. Because this analysis shows association rather than direction, both XKR3-to-partner and partner-to-XKR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by XKR3-low versus XKR3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR3→partner) and Y-score (partner→XKR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Cytoplasmic pattern recognition receptor signaling pathway →	+0.054	+0.347	<.001	.006	3	6
CNS	Nephron epithelium development →	-0.033	-0.319	<.001	<.001	3	6
SKIN	Melanosome organization →	+0.097	+0.475	.004	.004	3	5
SKIN	Pigment granule organization →	+0.097	+0.475	.004	.004	3	5
UPPER_AERODIGESTIVE_TRACT	Vacuole organization →	+0.052	+0.100	.001	.008	3	5
BONE	Glycosphingolipid catabolic process →	+0.175	+0.682	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 937 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by XKR3 expression — CNS

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